Volume :
2
Issue :
1
Abstract :
Fexofenadine Hydrochloride is an antihistamine drug used in the treatment of hay fever and similar allergy symptoms. It does not readily pass through the blood-brain barrier and causes less drowsiness than first generation histamine-receptor antagonists. Fourteen batches of rapid dispersible tablets of Fexofenadine Hydrochloride were prepared using Cross Povidone, Cross carmellose Sodium and Sodium Starch Glycolate as Superdisintegrants in different concentrations and in different combinations by Direct Compression method. Preformulation studies of Fexofenadine Hydrochloride were performed, from the FT-IR; the interference was verified and found that Fexofenadine Hydrochloride did not interfere with the polymers used. Fexofenadine Hydrochloride formulated as Rapid Dispersible Tablets gives best results. Also negligible side effects makes it superior and effective candidate for pediatric, geriatric, bedridden and psychotic patients.