Volume :

5

Issue :

1

Abstract :

Liquisolid technique was chosen to enhance the dissolution properties of Candesartan. The Candesartan liquisolid compacts were prepared by using PEG 400, propylene glycol as the nonvolatile liquid vehicles. Avicel PH 102 and Aerosil were used as the carrier and coating material, respectively. From the results obtained from executed experiments, it can be concluded that the preformulation studies like melting point, flow properties of Candesartan were compiled with IP standards. The FTIR spectra revealed that, there was no interaction between polymer and drug. Polymers used were compatible with Candesartan. Among the PG in 1:3 ratio (F7) was showing best release. Stability studies showed that there were no significant changes in physical and chemical properties of tablet of formulation F7 after 3 months. This research work has produced encouraging results in terms of increasing the in vitro dissolution of poorly soluble drugs such as Candesartan using liquisolid technology. The technique being simple and effective can also be extended to other poorly soluble drugs. The in vivo performance of the liquisolid compacts has to be studied using animal models to claim a complete success in the development of these formulations.