Volume :
1
Issue :
2
Abstract :
Vincristine is an anti-metabolite having an anti-cancer its having low aqueous solubility hence formulated microemulsion will increase its solubility and thus improves the oral bioavailability selection of nigella sativa oil is due to its anti-cancer property and the solubility of drug in oil (70mg/ml).micro emulsion was prepared by phase titration method using nigella sativa oil, tween 80, tween 20, water..8blank formulations were formulated based on various physical parameters clarity, stability, density, viscosity, ph, and electrical conductivity,3formulations were narrowed down, drug loaded in previously selected blank microemulsion formulation the particle size study was carried out by zeta analysis and the results proved that the formulations were micron sized. Ftir studies proved that there was not much interaction between the drugs in the formulation. In-vitro dissolution studies were performed for all the 17 formulations individually for both the drugs was found. The optimized formulation was sustained release this formulation was subjected to ex-vivo diffusion study and the permeation through the membrane was found.