Volume :
2
Issue :
4
Abstract :
The purpose of this research was to design and evaluate an oral pulsatile colon specific to achieve time and or site specific release of tramadol based on chronopharmaceutical approach tramadol a centrally acting analgesic and synthetic analog of codeine, it has asignificantly lower affinity for opiod receptors than codeine .indicated in the treatment of moderate to severe pain tramadol is used to treat postoperative dental ,cancer and as an adjuvant to nsiad therapy in patients with osteoarthritis. Tramadol was prepared by using pulisin cap technology with different polymervariation .and formulation parameter were optimized .all the formulation were evaluated for flow properties and in vitro drug release was carried out in ph 7.2 buffer using USPXXIV dissolution rate test apparatus at 100 rpm 370 C ± 50 C capsule are subjected to formaldehyde treatment. It is concluded these pulsincaps are the potential system for oral pulstaile colon specific for treatment of osteoarthritis.