Volume :
3
Issue :
3
Abstract :
Stavudine is a potent antiviral agent used in the treatment of chronic viral diseases such as AIDS/HIV, other viral infection. Such viral diseases requires long term drug therapy but the major drawback of antiretroviral drugs for the treatment of AIDS are their adverse effect during long term therapy, poor patient compliance and there huge cost. So it is necessary to formulate antiretroviral drugs in to a such delivery system, which provide uniform drug level for long period of time, reduce dose and side effect, better patient compliance and increases the safety margin for high potency drug .The objective of present work to develop and evaluate of sustained release matrix tablet of Stavudine by using hydrophilic polymer such as HPMC K4M and Methyl Cellulose. The tablet was prepared by direct compression method. The pre-compressive parameters for the blend and post-compressive parameters for the prepared tablets were evaluated. All formulations showed desired pre and post-compressive characteristics. FTIR study showed no evidence of drug excipient interaction. The optimized formulation was found to be F5, which showed 97% drug release at the end of 12hrs. It was concluded that the formulated stavudine matrix tablet using widely accepted and physiological safe polymer was capable of exhibiting sustained release for a period 12hrs.