Volume :
1
Issue :
1
Abstract :
Norfloxacin a fluoroquinoline derivative used as antibiotic requires multiple administration of drug, leading to fluctuation in plasma concentrations. The aim of present study is to formulate for sustained drug release. Norfloxacin microspheres (NM), by using various polymers like carbopol 934, Sodium Carboxy Methyl Cellulose (SCMC) using different drug : polymer ratios. Six formulations were prepared by using multiple emulsion solvent evaporation technique. NM were evaluated for parameters like angle of response, bulk density, particle size, drug content in microspheres, drug loading, encapsulation efficiency, In-vitro drug release studies. The prepared NM showed good flow properties, where spherical in shape with uniform surface morphology NM showed sustained release of the drug from the formulation for a period of 12 hours.