Volume :
4
Issue :
1
Abstract :
The present study was aimed to develop a novel multiparticulate delivery system by using solid dispersion method. Multiparticulate pellets are particularly useful in paediatric, geriatric, psychiatric and bedridden patients who have difficulty in swallowing. Glibenclamide is an anti diabetic drug belonging to BCS Class II , which is a poorly waterâ€soluble drug which leads to decrease in bioavailability. In this study Solid dispersion method is used for increasing the solubility of the drug by using carriers like PEG-6000 and PVP-K30. The aim of the present study was to develop the multiparticulate pellets of Glibenclamide to increase the patient compliance and to reduce the risk of dose dumping. Multiparticulate pellets were prepared by using Extrusion-Spheronization method using different grades of crosspovidone and sodium starch glycolate. The multiparticulate pellets were evaluated for compatibility, drug content, friability pellet size, sphericity, disintegration, dissolution studies. FTIR results indicated that there was no incompatibility between the drug and the excipients.