Volume :

5

Issue :

1

Abstract :

In the present work, microspheres of Glipizide using Sodium alginate along with Carbopol 934, HPMC as copolymers were formulated to deliver Glipizide via oral route.The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Glipizide microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, toxicity and difficult to remove traces of organic solvent completely. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymers used. Micromeritic studies revealed that the mean particle size of the prepared optimized microspheres was in the size range of 611µm and are suitable for microspheres for oral administration.Increase in the polymer concentration lead to increase in % Drug entrapment efficiency, Particle size, % swelling.The invitro drug release decreased with increase in the polymer and copolymer concentration.Analysis of drug release mechanism showed that the drug release from the formulations followed zero order kinetics with higuchis model of drug release.Based on the results of evaluation tests formulation coded F3 was concluded as best formulation.