Volume :

4

Issue :

4

Abstract :

Drug delivery via buccal route, using bioadhesive dosage forms offers such a novel route of drug administration. Buccal delivery involves administration of desired drug through the buccal mucosal membrane lining of oral cavity. Extensive first-pass metabolism and drug degradation in the harsh gastrointestinal environment can be circumvented by administering the drug via buccal route. The mucosal lining of oral cavity offers some distinct advantages. It is richly vascularized and more accessible for the administration and removal of a dosage form. Additionally, buccal drug delivery has high patient acceptability compared to other non-oral routes of drug administration. In the present study, an attempt was made to design and evaluate mucoadhesive buccal tablets of solifenacin. Different formulations of solifenacin having polymers at different concentrations were prepared by direct compression method. Drug and polymer interactions were investigated by Fourier Transform Infrared (FTIR) and no interactions were detected with the used polymers. solifenacin pure drug was evaluated for preformulation parameters. Among all formulations F2 and F8 were optimized with drug release 98.6% and 99.6% respectively. But mucoadhesion time for F8 was less than F2 (