Volume :
3
Issue :
2
Abstract :
Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. Due to sudden onset of attack, it is necessary to formulate anti hypertensive drug into such a delivery system, which provide immediate relief. The aim of present investigation was to prepare Mouth dissolving tablets of an Anti hypertensive drug Telmisartan. The solubility of poorly soluble drug was enhanced by preparing solid Dispersions of the drug with Poloxamer 407 & PEG 3350 in various concentrations by Kneading method. The optimized solid Dispersions (Drug: Poloxamer 407, 1:3 ratio) were further kneaded with suitable proportions of superdisintegrants such as; Crosscarmellose, Sodium starch glycolate and Crosspovidone. Mouth dissolving tablets of Telmisartan was prepared by direct compression method. The pre-compressive parameters for the blends and post-compressive parameters for the prepared tablets were evaluated. All formulations showed desired pre and post-compressive characteristics. FTIR study showed no evidence of drug excipient interaction. The optimized formulation was found to be F6. It was concluded that Mouth dissolving tablets of Telmisartan can be prepared by solid Dispersions of drug with Poloxamer 407 and combination of superdisintegrants provide complete and better dissolution within in shorter period of time. Hence effective Hypertensive treatment anywhere, and anytime particularly for geriatric, pediatric, mentally ill, bedridden and patients who do not have easy access to water.