Volume :
3
Issue :
1
Abstract :
The present investigation deals with formulation of Naproxen sodium Mouth dissolving tablets using super disintegrants .Naproxen sodium is an analgesic and NSAID, used for the treatment of Pain and inflammation caused by condition such as osteoarthritis and rheumatoid arthritis .However, Gastric discomfort caused by Naproxen sodium results in poor patient compliance associated with its conventional dosage form. Hence the present study is carried out with the view to develop Mouth dissolving tablets of Naproxen sodium, which produces rapid onset of action and minimizes gastric discomfort associated with it. Thus improves patient Compliance, enhances bioavailability and also reduces the dose of drug. In this study MDTs are prepared by direct compression method using four different super disintegrants in different proportions .The powder blend is subjected to precompression evaluation parameters including bulk density, true density, tapped density, cars index, Hausner’s ratio and angle of repose. The formulations are evaluated for weight variation, hardness, wetting time, water absorption test, disintegration time and in vitro dissolution studies and all formulations complies its Pharmacopoeial standards. The tablets are evaluated and the results compared for all four super disintegrants revealed cross povidone to be the most efficacious super disintegrant to formulate mouth dissolving tablets of Naproxen sodium as suggested by the dispersion time, disintegration time and drug dissolution profiles.