Volume :
2
Issue :
3
Abstract :
The ultimate dosage forms for pellets can be capsule or they may be compressed into disintegrating tablets. Interest in this area has been increasing continuously, since it offers some important pharmacological as well as technological advantages. Extrusion -Spheronization may be defined as a process in which a wet mass is extruded through a specific sieve with fixed diameter and subsequently spheronized into spherical particle called as spheroids, pellets or beads depending upon materials and process used for Extrusion –Spheronization. Controlled release pellets have minimum volume in size, greater surface area and more surface activity. The area of the drug loaded pellets release rate was also more. And also there was no need of disintegration time for pellets in capsules. Small volumes of pellets enter into the systemic circulation very fast. Moreover there was no accumulation of drug in the body. Drug release rate was more when compared with that of other formulations. Naproxen controlled release pellets were filled into capsules. It showed good results in formulation of stable dosage. The dissolution profile was determined for all the formulations. Formulation F9 was considered as optimized formulation in terms of percentage cumulative drug release, coating build up, chanelling agent ratio etc.