Volume :

3

Issue :

4

Abstract :

Migraine is a chronic disorder and characterized by splitting headaches. A combination of sumatriptan succinate and naproxen sodium was found to be effective. Time to reach Cmax and biological half-life of both drugs are different and hence optimum levels of both drugs cannot be maintained simultaneously in the blood when these drugs administered orally in the form of conventional tablet. Therefore the object of present study was formulation development in vitro evaluation of porous combination tablet dosage form containing Naproxen sodium as immediate release in 45 min and sumatriptan succinate as sustained release to maintain optimum plasma levels of both drugs at a time and for a prolonged period of 12hrs. And here using sublimating agents camphor, and superdisintegrants like SSG for immediate release and HPMC K100M polymer to sustain the drug release.