Volume :
2
Issue :
4
Abstract :
The present study focuses on the formulation of ethosomal gel of ciclopirox, an anti-fungal agent, for delivery as a carrier for transdermal application. The ethosomes were prepared using different concentrations of phospholipids (2-4 % w/v), ethanol (20-50 % w/v). They were formulated into 12 different formulations with different concentrations of phospholipids and ethanol. The drug release profile exhibited Higuchis and zero order kinetics. The optimized formulation was found to be EF7 containing 40 % w/v ethanol and 3% w/v lecithin. The optimized formulation was evaluated for particle characteristics and zeta potential. Ethosomal gel was prepared by incorporation of optimized ethosomal suspension into gel base. The ethosomal gel was characterized for physical appearance, pH, content uniformity, rheological behaviour, skin-retention, in-vitro drug release and stability. From the results it can fairly be concluded that ethosomes are capable of delivering ciclopirox into systemic circulation by transdermal route.