Volume :
2
Issue :
1
Abstract :
The floating drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The model drug is Lisinopril which has narrow absorption window, only 25% of the drug is absorbed and the remaining drug is excreted unchanged in urine. By increasing the gastric residence time of the lisinopril, the frequency of administration and drug wastage can be reduced The present study was carried out to develop a floating drug delivery system using gum karaya, chitosan and carrageenan as release controlling polymers to prolong the residence time of the model drug lisinopril in the stomach. The floating ability of gum karaya, chitosan and carrageenan was increased by addition of NaHCO3 as a gas-generating agent. The floating tablets were prepared by direct compression method and evaluated for pre compression and post compression studies. The lisinopril release through 20% gum karaya and 20% carrageenan was delayed by 12 hours when compared to a preparation available on the market which released the complete drug in 0.5 hours. The drug release study of lisinopril from the formulation follows zero order kinetics using a diffusion controlled mechanism. The results from the present study revealed that gum karaya and carrageenans provides the required delay in the release of drug and hence are ideal for the formulation of floating drug delivery systems.