Volume :
1
Issue :
2
Abstract :
The oral disintegrating tablets of furosemide with sufficient mechanical strength, acceptable taste and smaller disintegration time were achieved employing suitable superdisintegrants and other excipients at optimum concentration. FTIR studies revealed that there was no shift in peaks, indicating there is no interaction between furosemide and other ingredients used. Among three superdisintegrants used sodium starch glycolate showed better performance in disintegration time when compared to crospovidone and cross caramellose sodium used alone. In the invitro dissolution study comparison among all formulations, OF5 showed best results. So the formulation of OF5 was found to be best among all other formulations, because it has exhibited good taste and faster disintegration time when compared to all other formulations.