Volume :
2
Issue :
1
Abstract :
New era of Novel Drug Delivery System oriented towards increasing safety and efficacy of existing drug molecule through novel concepts like oral drug delivery system. Orally disintegrating systems have carved a niche amongst the oral drug delivery systems due to the highest component of compliance they enjoy in patients especially the geriatrics and pediatrics. In addition, patients suffering from dysphasia, motion sickness, repeated emesis and mental disorders prefer these medications because they cannot swallow large quantity of water. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in these dosage forms. However, the requirements of formulating these dosage forms with mechanical strength sufficient to with stand the rigors of handling and capable of disintegrating within a few seconds on contact with saliva are inextricable. Diltiazem Hcl is an anti-hypertensive drug. In the present research work an attempt has been made to formulate and evaluate mouth dissolving tablets of Diltiazem Hcl . Mouth dissolving tablets of Diltiazem Hcl were prepared by direct compresion using sodium starch glycolate, croscarmellose sodium and cros-povidone as superdisintegrants. The tablets prepared were evaluated for various parameters.