Volume :
2
Issue :
4
Abstract :
Formulation of Etodolac patches using different polymers like HPMC, EC alone and their combinations.
Characterization of patches.
In-vitro evaluation of patches for the release kinetics and related characteristic’s
Methods
In these study Etodolac transdermal patches was prepared by solvent casting method using polymer HPMC E5 and DMSO, used as a penetration enhancer. The prepared patches were evaluated for thickness, folding endurance, tensile strength, flatness, drug content uniformity, in-vitro permeation studies, kinetic study and calibrated using FT-IR. In vitro release study was performed by using Franz-diffusion cell.
Results
Among all prepared batches of TDD’S, batch F7containing HPMC E5 and EC (5:5) showed maximum rate of drug release of 87.825 ± 0.264 within 24 hr.
Conclusion
Etodolac transdermal delivery patches can be successfully formulated by using various ratios of EC and HPMC E5 alone and in combination. The appearances of the patches were transparent without air bubbles