Volume :

2

Issue :

4

Abstract :

The main objective of this study was to prepare and evaluate Alginate chitosan nanoparticles containing Moxifloxacin by ionic gelation method. The influence of different experimental parameters on the entrapment efficiency (EE), drug loading (DL), rate of recovery, percent drug released etc was evaluated. SEM indicated that nanoparticles have discrete spherical structure without aggregation. The average particle size was found to be 105.2±8nm. The in vitro drug release behaviour from all drug loaded batches was found to be sustained release over a period of 96 hours. Nanoparticles were stored at different temperatures and humidity as per ICH guidelines to check the stability.