Abstract :
In the past few decades, there has been an exponential growth in the field of herbal medicine and excipients. The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of itraconazole using natural gelling agents. Materials and Methods: Emulgel formulations of itraconazole were formulated using two types of gelling agents, namely xanthan gum and guar gum. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the formulated emulgel was studied by preparing various batches. The prepared formulations were evaluated for their physical appearance, viscosity, drug release, globule size, skin irritation test, antifungal activity, and stability. Itraconazole cream available in market was used for comparison with prepared formulations. Results and Discussion: All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The result of studied revealed that the optimized batch shows 96.04% release in 5 h.
Keyword :
Emulgel, guar gum, itraconazole, topical drug delivery, xanthan gum