Abstract :
Plan: Formulation, evaluation and optimization of Silversulfadiazine loaded film forming hydrogel using different hydrophilic polymers for the treatment of burns.
Preface: Burn injuries are very complex. One of the golden treatments in topicalburn is silver sulfadiazine (SSD).The film forming hydrogels (FFHs) are non-solid dosage forms that produce a flexible, occlusive film in-situ afterapplication on the skin or any other body surface.
Methodology: The hydrogel matrix was prepared with combinations of PVA & PVP, HPMCE5LV, and HPMC E15LV. The prepared FFHs were evaluated for their variousphysicochemical properties. The optimized formulation was selected by antimicrobial activity by agar diffusion technique. The in-vitro drug release study of optimized formulation was carried out and analyzed by potentiometric titrations.
Outcome: All the formulations showed better antimicrobial activity when compared with marketed SSD cream. The formulation F3 was found to be the optimized formulation.
Keyword :
Film forming hydrogel, Silver sulfadiazine, Potentiometry