Abstract :
The purpose of this research work was to develop and characterize a tacrolimus (TAC) gel using different polymers for the treatment of psoriasis. The physicochemical compatibility was confirmed between TAC and other excipients by Fourier transfer infrared. Formulated gels were characterized for drug content, viscosity, extrudability, skin irritation study, pH, in vitro diffusion study, and stability. Release of TAC from all formulations using dialysis membrane into a phosphate buffer pH 6.8 at 37°C was performed. Optimized batch was selected from this characterization study. Based on the data collected, it was revealed that TAC has proven to be a promising candidate for delivery through gel in the treatment of psoriasis
Keyword :
Carbopol 940, hydroxypropyl methylcellulose, psoriasis, tacrolimus, gel