Abstract :
Epalrestat is a noncompetitive reversible inhibitor of aldose reductase. Three first derivative
spectrophotometric methods have been developed for the estimation of Epalrestat in pharmaceutical formulations
using phosphate buffer (pH 5.0), phosphate buffer (pH 7.0) and borate buffer (pH 9.0).and Beer-Lambert’s law was
obeyed 0.1-20, 0.1-25 and 0.1-20 μg/ml respectively. The three methods were validated and applied for the analysis
of tablets.
Keyword :
Epalrestat, Tablets, Derivative spectroscopy, Validation