Abstract :
Transemulgel is a novel approach that could offer an alternative to traditional dosage form used on the skin
like ointments, creams, gels and patches. The polymeric formulation is applied as a liquid to the skin and
by solvent evaporation it forms an almost invisible in vitro film. Transdermal and dermal drug delivery
system can provide some advantageous results over traditional dosage forms, such as minimizing first-pass
metabolism in the GIT and liver, increasing bioavailability of drugs, the dose frequency, and strengthening
drug delivery profile. The aim of this study was to identify alternatives to traditional dosage forms to
minimize skin irritation, boost skin adhesion properties, increase drug release and patient acceptability from
aesthetic point of view. Because of their extraordinary rheological behavior, transemulgel are advantageous
in terms of ease of preparation, application, surface adhesion and ability to supply a wide variety of drugs.
Keyword :
Transemulgel, Transdermal drug delivery system, Gelling agents, Plasticizers.