Abstract :
In the present research work gastro retentive floating matrix formulation of Nifedipine by using Natural polymers
were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was
determined based on that calibration curve was developed by using different concentrations. Gas generating agent
sodium bicarbonate concentration was optimised. Then the formulation was developed by using different
concentrations of polymers Xanthan gum, guar gum and Karaya Gum as polymeric substances. The formulation
blend was subjected to various preformualation studies, flow properties and all the formulations were found to be
good indicating that the powder blend has good flow properties. Among all the formulations the formulations
Karaya Gum as polymer were retarded the drug release more than12 hours. whereas in low concentrations the
polymer was unable to produce the desired action. The formulations prepared with guar gum were also retarded the
drug release up to 12 hours (F6=96.32%). The optimised formulation dissolution data was subjected to release
kinetics, from the release kinetics data it was evident that the formulation followed zero order mechanism of drug
release.
Keywords: Nifedipine, Xanthan gum, guar gum and Karaya Gum, Floating Tablets
Keyword :
Nifedipine, Xanthan gum, guar gum and Karaya Gum, Floating Tablets