Abstract :
Oral route is most preferred route by medical practitioners and manufacturer due to highest acceptability of
patients. But oral drug delivery systems still need some advancement to be made because of their some drawbacks
related to particular class of patients which includes geriatric, pediatric and dysphasic patients associated with
many medical conditions as they have difficulty in swallowing or chewing solid dosage forms. The aim of this is to
highlight the potential role of fast dissolving drug delivery in achieving effective drug delivery of antihypertensive
drug. It gives rapid absorption and instant bioavailability of drugs due to high blood flow. As the fast-dissolving film
is taken through the sublingual route, rapid absorption of drug is possible, which finally leads to quick onset of drug
action and prevent the first pass-metabolism of the drug. Preformulation studies were done with
benazepril(API),polymers were HPMC E5,HPME E3LV,HPME 5CPS,film forming polymer and disintegrate as
maltodextrin, plasticizer as PEG, sweetener as aspartame, cooling agent as mannitol,colouring agent as amaranth,
salivating agent as citric acid. For above formulations evaluation parameters are (appearance, thickness uniformity,
weight uniformity, drug content uniformity, folding endurance, surface pH of film, in vitro disintegration time, in
vitro dissolution studies) were placed in pH 1.2(0.1N HCL) and the drug release were conducted. Kinetic data of
optimized drug is conducted (zero order kinetics, first order kinetics, Higuchi model, Korsmeyer–Peppas model).
Drug was released from the formulation F8 within 9 minutes. Based on the physico-mechanical properties and invitro
drug release.
Keywords: Anti-hypertensive, benazepril, HPMC E5, HPME E3LV, HPME 5CPS, PEG, pH 1.2, higuchi model,
Korsmeyer- peppas model
Keyword :
Anti-hypertensive, benazepril, HPMC E5, HPME E3LV, HPME 5CPS, PEG, pH 1.2, higuchi model, Korsmeyer- peppas model