Abstract :
The oral mucosa is vascularized where by absorbed drugs get direct access to the systemic circulation without first
pass metabolism. This present work is to formulate mouth dissolving film of Ezetamibe for enhanced bioavalibility.
Drug and excipients studies were conducted using FTIR. Oral films of Ezetamibe were formulated using HPMC E5,
as a film forming agent and propylene glycol as plasticize. And citricacid (salaviry stimulent), flavouring agents
(vennila) are used.The solvent casting method was used for the preparation of films. Ezetamibe oral film was
evaluated for folding endurance, thickness, weight variation test, surface pH, content uniformity,dissolving time and
in-vitro dissolution. No drug–excipients interaction was observed. The characterization studies depict the purity of
drug and all the excipients used in the formulation. The IR spectrum of mixture of Ezetamibe with all other
excipients does not show any changes which indicate its compatibility with other excipients. From the results, it can
be concluded that the fast dissolving oral film of Ezetamibe showed fast disintegration, dissolution of drug in
salivary pH. Thus the prepared fast dissolving films of Ezetamibe could be a better alternative for achieving rapid
oral bio availability.
Keywords: Ezetamibe, hypercholesterolaemia,HPMC
Keyword :
Ezetamibe, hypercholesterolaemia,HPMC