Abstract :
Diabetes is a metabolic disorder that characterized by hyperglycemia, glycomeia and hyperlipidemia. The aim of this
study was to investigate the oral hypoglycemic tablets using natural mucilage extracted from okra pod. Natural
polymers are economic, easily available and found useful as tablet binder. They also contain anti-nutrient content
which help in controlling blood sugar level. The aqueous extract of okra pod was precipitated using ethanol. The
precipitate was dried and stored in desiccators for further phytochemicals screening. Glipizide is a first third
generation sulphonylurea agent for the treatment of type 2 diabetes mellitus. The binder concentrations used in the
formulation were 0.5, 1.0, 1.5, 2 & 2.5 % w/w. The granules were evaluated for bulk density, tapped density, angle of
repose. The tablets were subjected to physicochemical studies thickness, friability, weight variation, hardness, in vitro
dissolution study. Diabetes was induced by single intra peritoneal injection of freshly prepared solution of
streptozotocin (45 mg/kg) and blood glucose level was monitored for 28 days. The optimized formulation reduces blood
sugar significantly in STZ induced diabetic rats in comparison to standard drug (Glipizide).This study has
demonstrated that mucilage of okra pod can be used for formulation of glipizide tablets.
Keywords: Okra pod, mucilage, Glipizide, tablets, antidiabetic activity
Keyword :
Okra pod, mucilage, Glipizide, tablets, antidiabetic activity