Abstract :
Omeprazole fast disintegrating tablets were prepared by using different superdisintegrants like crospovidone,
croscarmellose sodium and Sodium starch glycolate by direct compression. Precompression parameters were
conducted for all formulations blend and were found to be satisfactory. The prepared tablets were evaluated for
various parameters like content uniformity, hardness, friability, wetting time, water absorption ratio, disintegration
time and In-vitro dissolution. The results indicated that the tablets complied with the official specifications. The
disintegration studies shown that the all formulations disintegrated in less than 1 minute. The formulation F3 shown
less disintegration time of 15 seconds. The croscarmellose sodium and sodium starch glycolate shown more
disintegration time than crospovidone. In the present study, three Superdisintegrants representing each of the three
main classes of superdisintegrants differed in their ability to disintegrate model tablet into their primary particles
when used at the same w/w percentage concentration.
Key words: Omeprazole, crospovidone, croscarmellose sodium and Sodium starch glycolate
Keyword :
Omeprazole, crospovidone, croscarmellose sodium and Sodium starch glycolate