Abstract :
Ramipril is an angiotensin- converting enzyme (ACE) inhibitor, used to Hypertension (high blood pressure) and
congestive heart failure (CHF). These inhibitors relax (arterioles) the muscles around small arteries. They expand
the arterioles and allow to blood flow through more easily. This reduces blood pressure (B.P). Controlled release
matrix tablets of Ramipril were prepared by using three polymers, one of the hydrophilic polymer hydroxy propyl
methyl cellulose K15M (HPMCK15M) with four concentrations (drug: polymer ratios-1:1, 1:2, 1:3, 1:4), PVPK300,
and Karayagum by wet granulation method. The granules were evaluated for bulk density, tapered density,
bulkiness, angle of repose, Hausners ratio and compressibility index. In vitro release studies revealed that Ramipril
formulation with high proportion of HPMCK15M (1:4) was able to control the drug release for 12 hours
(85.4 1.26). The in-vitro drug release data, curve-fitting kinetic analysis and all the formulations followed the
mechanism of erosion and diffusion. All the formulations were subjected to stability analysis for stored at 45 2 C,
75 5 RH up to 45 days.
Keyword :
Controlled release, HPMC K15M, PVPK30, Karayagum, wet granulation, Ramipril, Hydrophilic polymer, ACE inhibitor