Extend of neuroendocrine differentiation in adenocarcinoma prostate needle biopsies


Article PDF :

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Article type :

Original Article

Author :

Girija C, Feroze M

Volume :

7

Issue :

4

Abstract :

Neuroendocrine differentiation in prostatic adenocarcinoma is now one of the emerging prognostic factor that determine treatment outcome. This study aims to identify the extent of neuroendocrine differentiation amidst the tumour cells in adenocarcinoma prostate with the help of immunohistochemical marker, Chromogranin A(CgA) and correlate with its Gleason score. A semiquantative scoring system was utilised to estimate and quantify cells having neuroendocrine differentiation. Results: Out of 40 cases of prostatic adenocarcinomas in needle core biopsies, 93% of patients with a Gleason score >6 showed CgA positivity of more than 5% and 2cases (16.6%) having Gleason score 9 showed >50% of CgA positive cells in the tumour area. Conclusion: Hence higher Gleason score correlated with higher degree of neuroendocrine differentiation in our study.

Keyword :

 Adenocarcinoma prostate, Neuroendocrine differentiation.
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