Abstract :
Growing Teratoma Syndrome (GTS) is a rare clinical entity associated with non-seminomatous germ cell tumors (NSGCTs) of the testis and ovary, initially described in the context of testicular tumors. GTS is exceptionally uncommon in the pediatric population, with only eight cases reported in the literature to date.We report a case of a 6 years old paediatric patient diagnosed with immature teratoma, who later developed progressive disease during chemotherapy, despite normalization tumo-markers. Surgical excision was performed, and histopathological examination confirmed mature teratomatous elements without any viable immature component, establishing the diagnosis of Growing Teratoma Syndrome.In the presence of a paradoxical clinical picture—showing radiological progression with normalized tumor markers after chemotherapy, the histopathology is key to confirming the diagnosis. Complete surgical excision is essential to prevent compressive complications. Prognosis is excellent, with
Keyword :
Alpha-fetoprotein (AFP), Growing Teratoma Syndrome (GTS), Lactate dehydrogenase (LDH)