Volume :
3
Issue :
1
Abstract :
To evaluate the wound healing activity of leaves of Mirabilis Jalapa L in experimentally induced diabetic rats using Excision wound model, Incision wound model, Dead space wound model. Healthy albino wistar rats (200-250gm) of either sex, were divided into three groups (n=6).Group I (control) receives plain drinking water. Group II (diabetic control-receives plain drinking water) and Group III (diabetic group- receives 1000mg/kg b.wt of Mirabilis Jalapa. In excision wound model percentage of wound contraction was measured on 3rd, 6th, 9th, 12th, 15th, 18th, 21st day. In Incision wound model the wound breaking strength was measured on the 10th day. In dead space wound model the wet and dry weights of granulation tissue was recorded from the animals after 10days of wounding. The hydroxyproline content was measuring absorbance at 540nm using colorimeter. The data was analyzed by one way ANOVA followed by Dunnet`s test. The values were expressed as Mean±SEM. **P