Abstract :
Introduction: Chronic kidney disease (CKD) is a global epidemic condition and nowadays it has become
a major public health concern imposing huge socioeconomic burden. In patients of CKD patients thyroid
profile gets deranged due to abnormal metabolism in the thyroid hormones.
Aim: The present study was planned to evaluate the thyroid hormones T3, T4, TSH ,blood urea and serum
creatinine levels as markers of renal function inpatients of CKD.
Materials and Methods: In the present case control study, 37 patients with CKD with and without
hemodialysis and 30 healthy age and sex matched controls were enrolled to evaluate the thyroid dysfunction
and renal function tests. Cases fulfilling inclusion criteria attending Nephrology Department and Dialysis
unit in King George hospital, Visakhapatnam were included in the study.
Results: In this study, out of 37 cases 27 CKD patients were having treatment without dialysis and 10 CKD
patients were on hemodialysis. 3(11%) cases out of 27 CKD patients without hemodialysis were observed
to be hypothyroid and 3(30%) cases out of 10 CKD on hemodialysis were hypothyroid. The incidence of
hypothyroidism is 16.2% in CKD patients.
Conclusion: In our study, the difference in mean values of T3 was statistically significant in cases
compared to controls unlike T4 and TSH which indicates association of lower T3 syndrome with CKD.
Keyword :
Points towards the association of low, T3 syndrome with CKD.