Abstract :
In chronic renal failure, there is gradual damage to kidneys. Minerals alter in renal failure patients because
of impairment in renal function.
Objective: To evaluate the significance of minerals in chronic renal failure patients was the focus of the
study.
Materials and Methods: This is a case-control study. The study included sixty individuals within the
age group of 30 -70 years and was selected randomly in the year 2018 over a period of six months in the
Department of Biochemistry and Nephrology of ASRAM medical college, AP. Thirty subjects were taken
as a control group (Group A) and thirty subjects of chronic renal failure who are clinically diagnosed based
on the creatinine value > 7.0 mg/ dl as cases (Group B). The parameters RBS, creatinine, urea, sodium,
potassium, magnesium, phosphorus, iron and calcium were analyzed by Automated Chemistry Analyzer;
Beckman Coulter AU 480.
Results: The subjects within the age of 30-70 years were taken. Comparison between the results of
controls and cases (CRF) of biochemical variables (RBS, creatinine, urea, sodium, potassium, magnesium
phosphorous, iron and calcium) has shown statistical significance. Comparison of CRF subjects, based
on gender has shown statistically no remarkable difference in RBS, creatinine, urea, sodium, potassium,
magnesium phosphorous, iron and calcium. Levels of all biochemical variables in CRF with hypertension
versus CRF with both hypertension and DM cases do not show any statistical significance.
Conclusion: Serum levels of RBS, creatinine, urea, potassium, magnesium and phosphorus showed a
remarkable increase in CRF patients w hen compared to the control group. Serum levels of sodium, calcium
and iron showed a remarkable decrease in CRF patients than those in the control group.
Keyword :
Chronic Renal Failure (CRF), Chronic Kidney Disease (CKD), CKD-mineral bone disorder
(CKD-MBD), Diabetes Mellitus (DM), End-stage renal disease (ESRD), and Random Blood Sugar (RBS).