Volume :

2

Issue :

1

Abstract :

The present study was carried out to evaluate the analgesic and anti-inflammatory activity of various fractions of Toluene, Ethyl acetate, Butan-2-one and N-Butyl Alcohol of Leucas cephalotes. The fractions of the plant material were evaluated for the analgesic activity by acetic acid-induced writhing test, Eddy’s Hot plate test in mice and formalin-induced test and anti-inflammatory activity was screened by Carrageenan-induced rat paw edema and cotton pellet induced granuloma formation in rat models. The test fractions were showed analgesic and anti-inflammatory effect in dose dependent manner and ethyl-acetate fraction was found to be most potent among the test fractions. At 150mg/Kg b.w.p.o dose Ethyl-acetate fraction significantly inhibited 68.98% writhing response and 73.52, 76.03% Formalin induced analgesic in mice. The fraction with same dose showed significant 65.35% inhibition of Carrageenan induced rat paw edema and 43.87, 40.64% anti-proliferative effect of cotton pellet in rats and also different fractions of Leucas cephalotes showed prompt analgesic and anti-inflammatory activity due to dual inhibition properties on COX-2 and 5-LOX.