Volume :
1
Issue :
3
Abstract :
Timolol Maleate is a non-selective adrenergic receptor blocking agent and it is used the treatment of hypertension. It requires multiple administration of drug, leading to fluctuation in plasma concentration. The aim of the present study is to formulate for sustained drug release Timolol Maleate microspheres (TM), by using ethyl cellulose using different drug: polymer ratios. Six formulations were prepared by using multiple solvent evaporation technique. TM were evaluated for parameters like angle of repose, bulk density, particle size, drug content in microspheres, drug loading, encapsulation efficiency, in-vitro drug release studies. The prepared TM showed good flow properties, where spherical in shape with uniform surface morphology TM showed sustained release of the drug from the formulation for a period of 12 hours.