Abstract :
Background: Salmonella enteric serovars Typhi and Paratyphi are known to cause enteric fever. Multidrug resistance in S. Typhi and S.Paratyphi has emerged as a cause of concern.
Aims: To evaluate antimicrobial susceptibility patterns of Salmonella enteric serovar Typhi (S. Typhi) and S.Paratyphi obtained from blood culture.
Materials and Methods: All S. enteric isolates obtained from blood cultures of clinically suspected cases of enteric fever coming to microbiology laboratory, Nirmal hospital, from January 2015 to September 2017 were included in the study. Antimicrobial susceptibility patterns were determined using commercial antimicrobial disks chloramphenicol (30 g), nalidixic acid (30 g), ampicillin (10 g), azithromycin (15 g), cotrimoxazole (1.25/23.75 g), ciprofloxacin (5 g), and ceftriaxone (30 g). Antimicrobial
susceptibility testing was performed in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines of respective year by KirbyBauer disc diffusion method.
Result: Total 330 isolates of salmonella are there out of that 298 is Salmonella typhi. 32 are Salmonella para A, while 1 is of Salmonella para B. Enteric fever cases pick month are April, May, June and July. Sensitivity to first line drugs are > 80%, Nalidixic acid resistant Salmonella (NARS) are 79%, while Multi drug resistant (resistant to ampicillin, chloramphenicol and co-trimoxazole all three)Salmonella are 3%.
Conclusion: Periodic evaluation of antibiotic susceptibility pattern is necessary to see changing pattern of antibiotics. Evaluation of Nalidixic acid resistant Salmonella and periodic evaluation of multi drug resistant Salmonella is also important as emergence of MDR strain is observed in our study.
Keyword :
Multi drug resistant, Nalidixic acid resistance, Salmonella typhi, Typhoid