Abstract :
Background: Platelet derived growth factors have been used as topical adjuvant therapy in chronic cutaneous ulcer. However the clinical evidence for effectiveness is limited. Therefore, this study was performed to evaluate the efficacy of topical platelet rich fibrin (PRF) dressing in the treatment of chronic cutaneous ulcer.
Aims: To evaluate the efficacy of topical platelet rich fibrin (PRF) dressing in the treatment of chronic cutaneous ulcer in comparison to conventional dressing.
Methods: An assessor-blinded, parallel group, randomized controlled trial was undertaken in 50 patients with chronic cutaneous ulcers of more than 6 weeks duration attending the outpatients, department of dermatology, BPKIHS, Nepal and followed up for 8 weeks. All patients were 18 years or older with ulcers size >0.5 cm2 to ?50cm2, baseline hemoglobin >9 gram/dl, platelets >1,00,000 cells/cm3, Serum protein concentrations above 6 gram/dl, fasting blood glucose
Keyword :
Ulcer, Platelet rich fibrin, Dressing, Healing.