Abstract :
Amniotic membrane transplantation is the newest approach to limbal stem cell transplantation for
the reconstruction of ocular surface disorders. Amniotic membrane grafting helps in promoting
epithelialisation, decreasing inflammation and suppressing fibrosis.
Purpose: To evaluate the use of amniotic membrane graft in patients coming to Dr B.R. Ambedkar Medical
college OPD and IPD with various ocular surface disorders.
Materials and Methods: The prospective interventional study was conducted over a period of 18 months
from June 2017 to November 2018 at DR. B. R. Ambedkar medical college and hospital, Bengaluru.
A total of 46 eyes of 46 patients were taken into the study. Consecutive patients with ocular surface
disorders including primary pterygia and chemical injury underwent amniotic membrane transplantation
and were followed for 6 months.
Results: In our study, 46 patients were enrolled including 26 males and 20 females with mean age of
43.3 /- 12.97 years. Of these, there were 40 patients with Pterygium (87%), 6 patient’s had chemical burn
(13%). Out of 40 cases with primary pterygium, 35 cases (87.5%) showed no recurrences at the 6th month
of follow up, 5 cases (12.5%) showed superficial vascularisation and re-growth upto 2mm crossing the
limbal margin. The recurrence was early in two cases (5%) and late in three cases (7.5%). Out of 6 cases
with chemical injury, 4 patients (66.6%) had successful outcome.
Conclusion: Amniotic membrane transplantation is a safe and effective surgical technique for ocular
surface disorders.
Keyword :
Amniotic membrane transplantation, Ocular surface disorders.