Volume :

4

Issue :

2

Abstract :

Orally disintegrating tablets (ODTs) are getting popularity over conventional tablets due to their convenience in administration and suitability for patients having dysphasia (difficulty in swallowing). Zolmitriptan is a selective serotonin receptor agonist. The absolute bioavailability is only approximately 40% due to extensive hepatic first pass metabolism (CYP1A2-mediated). Hence the main objective of the study was to formulate oral disintegrating tablets of Zolmitriptan to achieve a better dissolution rate and further improving the bioavailability of the drug. Orally disintegrating tablets prepared by direct compression method by using, Cross povidone, Cross carmellose sodium, Sodium starch glycolate, were prepared and evaluated for the precompression parameters such as bulk density, tapped density, compressibility index , angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, disintegration time and in-vitro dissolution profile found to be satisfactory. Among these F1-F6 formulations, F6 showed maximum dissolution rate with drug release (94.4%) within 10 minutes and it containing Crosspovidone as a superdisintegrant showed minimum disintegration time within 15 seconds and the formulation (F6) shows the maximum drug content 95.9%. In all the f1-f6 formulation are subjected to the kinetic studies, the results shows, best fit in first order drug release and followed by the ‘n’ value shows between (0.002-0.089), follows Fickian’s release mechanism.