Volume :
5
Issue :
3
Abstract :
The objective of this study was to evaluate the effect of formulation variables on the release properties, floating lag time, and hardness, weight variability, compressibility index, hausners ratio, angle of repose and invitro dissolution studies by developing floating tablets of Ranitidine hydrochloride by increasing its bioavailability. Ranitidine is a H2 receptor antagonist having short biological half life (2-3.5 h), absorption in the initial part of the small intestine and 50% absolute bioavailability of drug favour development of sustained release floating formulation. Floating matrix tablets of Ranitidine were developed using different effervescent salts and polymer combinations. The tablets were prepared by direct compression technique, using polymers such as carboxy methyl cellulose (CMC), Carbopol in combination. Sodium bicarbonate, citric acid, stearic acid was incorporated as a gas-generating agent. The effects of citric acid and stearic acid on drug release profile and floating properties were investigated. The addition of stearic acid reduced the drug dissolution due to its hydrophobic nature. The formulation was optimized on the basis of acceptable tablet properties, floating lag time, total duration of floating and in-vitro drug release.