Abstract :
Background: Laryngoscopy and endotracheal intubation are potent stimuli causing increased sympathoadrenal activity. The objective of this study is to assess and compare the effects of intravenous fentanyl versus a combination of intravenous fentanyl and paracetamol in blunting the hemodynamic responses to laryngoscopy and endotracheal intubation.
Materials and Methods: Sixty patients of ASA status I and II, aged 18-60 years of either sex posted for surgeries under general anaesthesia were selected. Patients in group A received intravenous fentanyl 2mcg/kg. Patients in group B received intravenous fentanyl 2mcg/kg and paracetamol 15mg/kg. After intubation vital parameters were recorded at 1, 2, 4 and 6 minute and later once every 10minutes.
Results : After intubation, there was an initial increase in heart rate in both groups. However, this was significantly higher (p=0.004) with group A as compared to group B and remained significantly high for another 6 minutes(p=0.03).
Results There was an increase of mean arterial pressure after intubation in both the groups, however, this was significantly higher in group A and remained significantly high for 6 minutes as compared to group B[p=0.003]. Mean SpO2 was similar in both the groups, and there were no complications during the study.
Conclusion: Intravenous fentanyl and paracetamol is more effective in blunting the hemodynamic responses due to laryngoscopy and endotracheal intubation when compared to intravenous fentanyl alone.
Keyword :
Intubation response, Laryngoscopy, Paracetamol, Fentanyl