Abstract :
Introduction: Vildagliptin, an antihyperglycemic drug, is having high water solubility and shorter elimination half-life. This leads to administer vildagliptin frequently to maintain its therapeutic efficacy. So the Formulation of vildagliptin microspheres might be beneficial in overcoming the side effects of the conventional drug delivery systems during the prolonged treatment.
Objective: The aim of the work was to evaluate and fabricate the microspheres, which improved the absorption of drug and increase the release kinetics and also to study the effect of formulation variables.
Materials and Methods: The microspheres of vildagliptin were formulated by solvent evaporation technique. The formulation variables were the concentration of Ethyl cellulose (EC), Polyvinyl alcohol (PVA), and stirring speed. The resulting microspheres were evaluated for percentage yield, percentage entrapment efficiency, particle size, surface morphology, drug release rates.
Results: The morphological structure of the microspheres revealed spherical shaped structures. Good entrapment were observed. The in vitro drug release was found to be controlled.
Conclusion: Results indicated that physicochemical properties of microspheres strongly affected by the presence of drug/polymer ratios, changing the concentrations of them and effect of variables.
Keyword :
Vildagliptin, Ethyl cellulose, Polyvinyl Alcohol, Dichloromethane, Microspheres