Abstract :
Type 2 diabetes is associated with bad health consequences. The current study focused on the effect of Moringa olifera (MO) extract on some metabolic and biochemical parameters in induced type 2 diabetic albino rats. Twenty-eight albino male rats were selected and randomly divided into 4 groups. The control rats fed on a standard balanced diet and the second group fed standard balanced diet and gavaged with MO extract 50 mg/kg b.wt. The third group was a diabetic group that was induced to type 2 diabetes by high dietary fat for 8 weeks followed by streptozotocin (STZ) 25 mg/kg intraperitoneal (i.p.) while the fourth group was induced to type 2 diabetes and gavaged with MO extract 50 mg/kg b.wt. Treatment was continued for 4 weeks and, final body weight was recorded. Serum Lipid Profile, insulin resistance, super oxide dismutase (SOD), tumor necrosis factor alpha (TNF-?), resistin and liver enzymes were determined. Histopathology to hepatic tissue was also done. Results revealed a significant reduction in final body weights of diabetic rats than control. Serum lipid profile was deteriorated in the diabetic group. Insulin resistance, TNF-?, resistin and liver enzymes were significantly upregulated (P
Keyword :
type 2 diabetes; moringa extract; Rat; Insulin resistance; TNF-?