Abstract :
Aim: The study was designed to evaluate the Antidiabetic activity of ethanolic leaves extract of P. deltoides.
Method: The P. deltoides ethanolic leaves extract was tested for the presence of various phytoconstituents
using standard procedure. The leaves extract was tested for its hypoglycaemic property in healthy albino rats
and glucose loaded rats. The effect of extract was evaluated for its antidiabetic action in alloxan induced rats.
The effect of extract on heart and kidney was determined by measuring biomarkers like total cholesterol,
triglycerides, HDL, creatinine, BUN, CPK and protein in diabetic rats. The histopathology of pancreas was
studied to support the experimental results.
Result: The P. deltoides ethanolic leaves extract revealed the presence of variety of chemical constituents like
glycosides, tannins, amino acids, alkaloids, protein, flavanoids, terpenes, phenols, saponins. The P. deltoides
leaves extract exhibited significant reduction in blood glucose level in healthy albino rats and overloaded
glucose levels. The extract exhibited significant reduction in blood glucose level in alloxan induced diabetic
rats. The percentage of reduction was highest at 500 mg/kg dose of ethanolic extract at 48.55% at 7th
day of the
treatment. The extract protected experimental animals against cardiotoxicity and nephrotoxicity in diabetic and
normal animals.
Conclusion: The ethanolic extract of P. deltoides exhibited significant hypoglycaemic property in healthy and
diabetic albino rats. The extract protected the diabetic albino rats agains
Keyword :
he ethanolic extract of P. deltoides exhibited significant hypoglycaemic property in healthy and diabetic albino rats. The extract protected the diabetic albino rats agains