Abstract :
Introduction/ Purpose: Mean Platelet Volume (MPV), an indicator of platelet activation, is a new risk factor for atherothrombosis and an important marker for the increase in thromboembolic diseases. MPV/ platelet ratio is considered as a risk factor for various diseases such as myocardial infarction. In this study, we aimed to investigate the possible effect of ISO on blood cell counts especially MPV and MPV/ platelet ratio.
Materials and Methods: 75 patients, between the ages of 18-25 with moderate or severe acne vulgaris and using oral isotretinoin (0.5 mg/ kg) were included in the study. Platelet count and MPV values of patients (pre-treatment and 3 months after the treatment) were recorded retrospectively.
Results: The mean age of patients was 23.32 3.44 years. 40 patients were female and 35 were male. MPV levels and MPV/ p ratio of “before treatment period” were significantly higher than the “after treatment period” (p
Keyword :
Acne vulgaris, İsotretinoin, MPV, Platelet, Thromboembolism risk