Volume :
2
Issue :
2
Abstract :
Losartan bioadhesive tablets were prepared by direct compression method. The tablets were evaluated for pre compression and post compression parameters, swelling studies and in-vitro drug release. The formulation with desired drug release was tested for stability. The formulation F8 was selected as the best formulation, as the release of Losartan from the formulation was found to be zero order kinetics and Korsmeyer-Peppas model. The optimized formulation was found to have good mucoadhesive strength in sheep gastric mucosa and showed drug release up to 12 hours (99.8 %).Therefore, bimodal drug release pattern was successfully achieved through the formulation of bioadhesive tablets in this study. Formulating bioadhesive tablets of losartan increased the bioavailability to 99.8 % with the use of polymer carbopol.