Volume :

4

Issue :

1

Abstract :

The aim of present work is to develop and validate simple, sensitive and specific Spectrophotometric method for the determination of simvastatin, a hypolipidemic drug in pure form and in pharmaceutical formulations.UV-Spectrophotometric method, which is based on measurement of absorption of U.V. The maximum wavelength in solvent system employed for determination of simvastatin was estimated at 233 nm in pH 6.8 phosphate buffer. The linearity range was found to be 0.01- 0.08 µg/mL(R2=0.999). The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The optimum conditions for analysis of the drug were established. The drug obeyed the Beer’s law and showed good correlation. Beer’s law was obeyed in concentration range 0.01-0.08µg/ mL The method was found to be simple, accurate, precise, economical and robust. This method has been statistically validated and is found to be precise and accurate.