Volume :
1
Issue :
1
Abstract :
A simple efficient, precise and accurate Simultaneous equation method have been developed for the Simultaneous estimation of Eprosartan Mesylate and Hydrochlorothiazide in pure and in fixed dose combinations. In this method, UV Spectra of Eprosartan Mesylate and Hydrochlorothiazide were overlained. The linearity ranges for Eprosartan Mesylate and Hydrochlorothiazide were 6-36μg/ml and 1-10μg/ml, respectively. The proposed procedures were successfully applied for the simultaneous determination of both drugs in the laboratory prepared mixtures and in commercial tablet preparations. The validity of the proposed method was assessed by applying the standard addition technique where the percentage recovery of the added standard was found to be 99.36 ± 0.701 and 98.9 ± 0.728 for Eprosartan Mesylate and Hydrochlorothiazide, respectively. The proposed procedure is rapid, simple, require no preliminary separation steps and can be used for routine analysis of both drugs in quality control laboratories. The results of analysis have been validated statistically and by recovery studies confirmed the accuracy of the proposed method.